Diabetes was induced in Wistar rats by single intraperitoneal administration of alloxan monohydrate (150 mg/kg). Alloxan-treated nondiabetic rats displayed marked interstitial nephritis in unprotected kidneys, while protected kidneys were normal. This method has however be questioned by recent research work as an appropriate technique for the induction of diabetes. We demonstrate that short-term exposure to alloxan or to XO/HX leads to a temporarily elevated insulin release from isolated pancreatic islets. Effect of Glutathione on .LAMBDA. The fruit extract of P. farcta showed decreasing in the level of ALP in alloxan-induced diabetes rats. Free radicals have been implicated in the pathophysiology of diabetes 1, 2] and oxidative stress may be a common pathway linking diverse mechanisms for the complications in diabetes . The present study aimed to determine the effects of gymnemic acids derived from GI tea on adipogenesis. Cells expressing the GLUT2 transporter were susceptible to alloxan toxicity due to the uptake of alloxan by this specific glucose transporter isoform. Diabetes was done by a single dose of 120 mg alloxan/kg b.w with subcutaneously injection. Although alloxan-induced diabetes is widely used in the laboratory to mimic diabetic pathology and for screening antidiabetic drugs, there has not been any comprehensive research in vivo on its diabetogenicity. Changes in canine plasma glucose, immunoreactive glucagon (IRG), pancreatic polypeptide (PP) and insulin (IRI) were studied during the acute development of diabetes mellitus after iv alloxan injection. The weight of the body of animals with diabetes decreased, and the glucose concentration increased in Diabetes was induced by intra peritoneal injection of 120 mg/kg Alloxan. Glucose blocked the decrease of cellular NAD+ level, but did not abolish the increase of cytosolic Ca2+. In addition, it has been widely used to produce experimental diabetes in animals such as rabbits, rats, mice and dogs with different grades of disease severity by varying the dose of alloxan used. of this diabetogenic agent were administered to fasting rats. Roots, fruits, and leaves of P. farcta, were extracted by n-hexane, ethyl acetate, and methanol. It is believed that psychiatry clerkship can improve communication of pharmacists with psychiatric patients. Background: Diabetes mellitus is still a problem in Indonesia, related to the number of organs involved. As a result of the streptozotocin action, B cells undergo the destruction by necrosis. Purpose: This research to determine activity of amla fruit extract in reducing blood glucose levels at balb/c mice induced with alloxan. of CSP-ZZEE. A mechanism based on known reactions of GSH and dialuric acid is proposed. Concentration of H2O2, lipid peroxidation (TBARS) and nitrite was increased (P < 0.05) whereas level of tissue protein, glutathione content (GSH) and antioxidant enzymes decreased in pancreas, liver and kidneys as compared to control group. To review the advantages and disadvantages of different glucose-lowering agents, with an emphasis on the role of thiazolidinediones (TZDs). Results Two groups without the disease (each group, n = 8) (sedentary control and trained control), as well as a sedentary diabetic group (n = 8) were included. The last group was orally submitted to the amyral solution 0.1 mg/kg after being injected with alloxan 120 mg/kg. According to research conducted by I Ketut Adnyana, et al, there is a decrease in blood glucose levels from noni fruit extract with a dose of 500 mg/kg BW and 1000 mg/kg BW. Adjuvant therapy is needed considering the long-term therapy that must be consumed by patients. Cherry as a traditionally used plant for treatment of diabetes, is packed with powerful plant pigments called anthocyanins. The effect of alloxan-diabetes has been attributed to inhibition of PFK by an increased concentration of citrate in the diabetic muscle 2-6 . P60 AM 20542-03/AM/NIADDK NIH HHS/United States. No effect on retrogression could be demonstrated within periods lasting up to a maximum of 4 months after the cessation of cholesterol feeding. i.p.) While no changes were seen in total cholesterol levels, a significant decrease was observed in plasma triglyceride levels, in the alloxan-induced diabetic rats after AECS treatment with both doses, as compared to the same groups before treatment. It has been demonstrated that raisins possess a low-to-moderate glycemic index, which makes them a healthy snack. The beta-cell toxin alloxan, which produces oxygen radicals, is a model substance in studies of type 1 diabetes. In contrast, glucose is shown here to be the only sugar with a dual protective effect both through inhibition of alloxan uptake through the plasma membrane like 3-O-methylglucose and through protection of the glucokinase sugar binding site against alloxan inhibition of the enzyme like mannoheptulose. Indian J ExpBiol 2001;39:748-59. Alloxan diabetes has been produced in rats, rabbits, dogs, monkeys, and cats (Goldner and Gomori, 1944). These results suggested that CAP was probably a beneficial ingredient for alleviating H2O2-induced oxidative stress and DON-induced cell inflammation and apoptosis and preventing hyperglycemia. Results: Both the onset and fasting blood sugar monitoring showed a significant decrease in the mean average blood glucose level of the mice. 3), ... higher in alloxan-induced diabetic rats compared to healthy rats. The aim of the experiment was to investigate the mechanism of harmful alloxan action in vivo. Our results are consistent with the central importance of selective uptake of alloxan through the low affinity GLUT2 glucose transporter for the pancreatic beta-cell toxicity and diabetogenicity of this substance. Addition of ferritin to the reaction system at concentrations below 50 micrograms/ml caused the strand breaks of DNA in a concentration-dependent fashion. Apoptosis was found only following nitric oxide exposure. Diabetes mellitus (DM) is a metabolic disorder in the endocrine system resulting from a defect in insulin secretion, insulin action or both of them. Antioxidant therapy has been shown to effectively attenuate or even prevent the development of prolonged depression of contractility in many studies. Results from the present study revealed that administration of alloxan results in hyperglycaemic state as evident in by marked increase in blood glucose level. While a significant increase was observed in urea and creatinine of treaded DZZ group. Diabetes in rodents is induced by injecting alloxan or streptozotocin which induce diabetes while producing ROS leading to demolition of pancreas β-cells [8, 9]. and It is renowned for the medicinal properties of gymnemic acid and its ability to suppress glucose absorption. Keywords: starch bengkuang_Pachyrizus erosus_preparation gel_HPMC. The current study was conducted in the College of Education for Girls/ department of Biology/ animal house,50 male albino rats belonging to the Sprague Dawley strain were used. We conclude: 1) alloxan per se is distinctly nephrotoxic; and 2) the glomerular endothelium and epithelium are involved early in the course of experimental diabetes. dose of 120mg/kg body weight) and left untreated or treated with taurine (1% w/v, orally, in water) for three weeks either from the day of ALX exposure or after the onset of diabetes. All students in the rotation filled the III, IV and V after a 24-h fasting period by intraperitoneal administration of 5% solution of alloxan monohydrate Our results suggested that GiA-7 and stephanosides C and B from GI tea could help to prevent obesity. The combination of HF with metformin elicited a greater degree of hypoglycemic activity, which was reflected both on blood glucose level as well as other biochemical parameters studied. Results: Gel from starch bengkuang was evaluated for 3 weeks, from the research starch bengkuang with gelling agent HPMC can be formulated into gel preparations, Gel with a concentration of HPMC 3% in F1 is the best preparation. Free radicals may produce cytotoxicity to pancreatic islets under pathophysiological conditions. The administration of the extract was lasted for 11 days. Gel made in 3 formulas at concentration of starch bengkuang every formula 5 gr with different HPMC F1,F2,F3 with a concentration of 3%,5%,7%. reduced the severity of diabetic symptoms. After 30 days, lipid/lipoprotein profile, aspartate aminotransferase, alanine aminotransferase, muscle damage ((creatine kinase (CK) and lactate dehydrogenase (LDH)), and oxidative stress (malondialdehyde (MDA), sulfhydryl groups (SH), and ferric reducing antioxidant power) were evaluated. All animals were followed and sacrificed after 9 weeks. The cytotoxic action of both these diabetogenic agents is mediated by reactive oxygen species, however, the source of their generation is different in the case of alloxan and streptozotocin. Graded doses (200 mg/kg and 400 mg/kg) of ethanol extract of Plectranthus amboinicus were studied in both normal and alloxan-induced diabetic rats for a period of 15 days. Diabetes Care 1998;12:553-64. effects of Portulaca oleracea extract in alloxan induced diabetic rats Basma K. Ramadan1, Mona F. Schaalan2* and Amina M. Tolba3 Abstract Background: Diabetes is a major public health concern. Given the important role of glucokinase as a glucose sensor, and our findings on the effects of alloxon on liver glucokinase activity we propose that the effects on the liver are the primary contributor to pathogenesis in alloxan-induced diabetes. Keywords: Alloxan, methanolic extract, free radicals, diabetes, antioxidants, DPPH assay. Results: Amla (Phyllanthus emblica L.) fruit extract at a dose of 40 mg / 20 g BW was equivalent to positive control of glibenclamide dose 3 mg / 20 g BW compared to the treatment group at a dose of 10 mg / 20 g BW and 20 mg /20 g BW. b) Acute alloxan diabetes: in general, changes similar to, but greater in magnitude than found in starved, normal rats, except for an unchanged 2-oxoglutarate level ; moreover, significant increases in lactatelpyruvate and 3-hydroxybutyrate/acetoacetate ratios and a … of reduced glutathione, catalase activity, superoxide dismutase activity, glutathione peroxidase and glutathione Keywords: Diabetes mellitus, Insulin resistance, Zingiber officinale, Malonydealdehyde. [Morphological study of the renal parenchyma (the tubule system and interstitial tissue) of Wistar rats in shock induced by experimental with E. coli infection]. Alloxan, a glucose analogue, is a toxin that damages the pancreatic β cells, thus severely diminishing the levels of insulin, ... [11] In several studies, under in vivo conditions (experimental mice) alloxan is used for inducing diabetes by disturbing β cells of the pancreas. The fifth and sixth groups were injected with alloxan 120 mg/kg, and then was orally dosed with astaxanthin extract 250 and 500 mg/kg respectively. The islets cells showed atrophy in size with cellular necrobiosis associated with cystic dilatation and luminal eosinophilic casts. Oleander Stem and Root Standardized Extracts Mitigate Acute Hyperglycaemia by Limiting Systemic Oxidative Stress Response in Diabetic Mice. Metformin is recommended for initial drug therapy; TZDs, sulfonylureas, and insulin are useful options as add-on therapy for patients whose A1C levels remain >or= 7% despite treatment with metformin and lifestyle interventions. Alloxan can also inhibit calmodulin activity which inhibits insulin secretion, ... An experiment was conducted in 30-mixed white mice of uniform age (4weeks) and about (18)(19)(20)(21)(22)(23), ... Injection of alloxan in mice is usually used in modelling hyperglycemia, which is similar to the diabetic patients. Objective: To explain the effect of hyperbaric oxygen in reducing blood glucose levels, and repairing histopathological damage to the pancreas and liver. The induction of cellular stress by high glucose, high oxygen, and heat shock treatment did not affect antioxidant enzyme expression in rat pancreatic islets or in RINm5F cells. 75 mg/kg b.w. It was found that the administration of hydrogen peroxide led to the disturbance of the barrier properties of plasma membranes only when the cells were preincubated, The mechanism of the reaction between alloxan and GSH has been studied in the presence and absence of superoxide dismutase. Viability of the cells was determined using a microtitre plate-based 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay. Protein glycation, the most important source of free radicals, is leaded by hyperglycemia. Among the tested standard compounds, rutin and isoquercetin were detected in the examined species. Through stable transfection, however, we were able to increase catalase and glutathione peroxidase gene expression in RINm5F cells, resulting in enzyme activities more than 100-fold higher than in nontransfected controls. (2006), 7 (4), 391 395 Hypoglycemic effects of vanadium on alloxan monohydrate induced diabetic dogs Joo-Min Kim, Jin-Young Chung, Sooeko-Yn Lee, Eun-Wha Choi, Min Impact statement inhibitory effect of alloxan diabetes on the development of cholesterol athero- sclerosis is minimized. With GSH: alloxan or dialuric acid molar ratios of greater than 8-10:1, redox cycling was almost completely suppressed. Significant decreases in blood glucose (25%) and triglyceride levels (48%) were also observed in the alloxan-induced diabetic rats after 4 days treatment with AECS (200 mg/kg, p.o.). reductase activities in liver and kidneys tissue. Intramuscular or intraperitoneal injection of a single alloxan dose (300 mg/kg) is shown to cause a temporary, modest rise in blood glucose levels in the Chinese hamster (Boquist, 1967). Objective: The objective of the study was to study the silymarin’s pancreatoprotective effect in alloxan-induced Type I diabetes mellitus. The present study clearly indicated a significant anti-diabetic activity with the seed powder of T. foenum-graecum and supported the traditional usage of the seed powder by Ayurvedic physicians for the control of diabetes. from the tail vein and measured glucose level in the collected blood using a portable glucose meter (Gamma-M). Diabetes mellitus was induced by intraperitoneal injection of alloxan monohydrate (120 mg/kg) body weight7. Actually, rats were single injected intraperitoneally with a freshly prepared solution of alloxan monohydrate in normal saline at a dose of 150 mg/kg b.w., freshly dissolved in NaCl 0.9% buffer (pH 7). Propolis is one of the hive products that have been used extensively in folk medicine. The research was conducted on 40 white laboratory rats kept in the vivarium of the Institute questionnaire was adopted from three commonly used tools: Balon Attitudes towards Psychiatry, Mental Illness Methods: A total of 24 male Wistar rats were divided into four groups (n=6): Group I normal control, Group II, Group III, and Group IV were induced diabetes with alloxan. Severe diabetes was modelled using a single intraperitoneal injection of 500 mg/kg alloxan in 0.2 mL of physiological saline, and physiological saline was injected into the control mice. It was also observed that glucose given 20 min before alloxan injection only partially protected against the deleterious effects of alloxan. Anti-diabetic Activities of Zizyphus spina-christi Seeds Embryos Extract on General Characteristics of Diabetes, Carbohydrate Metabolism Enzymes and Lipids Profile in Rats, The Hypoglycaemic and Hypolipidemic Effects of Aqueous Extract of Alkanna strigosa in Alloxan Induced Diabetic Rats, Effect of Glibenclamide and Tomato lycopene extract on some biochemical parameters in serum of alloxan Induced diabetic rabbits, Pancreato-protective PANCREATOPROTECTIVE EFFECT OF SILYMARIN ON OXIDATIVE STRESS IN ALLOXAN-INDUCED HYPERGLYCEMIA IN MALE WISTAR RATS, Leaf extract of Morinda lucida improves pancreatic beta-cell function in alloxan-induced diabetic rats, Antihyperglycemic, antidyslipidemic and antioxidant properties of hydromethanol extract of Eremomastax speciosa leaf in alloxan monohydrate-induced hyperglycemic rats, Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome—Strategies for In Vivo Administration: Part-II, Analysis of Metformin on Endogenous Antioxidants and Oxidative Stress in Mice Brain Tissue of Alloxan-Induced Diabetes, Ethanolic extract and ethyl acetate fraction of Coutoubea spicata attenuate hyperglycemia, oxidative stress and muscle damage in alloxan-induced diabetic rats subjected to resistance exercise training program, The effects of Areca cathecu and Ficus deltoidea methanolic extracts on glycemic and reproductive parameters in alloxan-induced diabetic rats, HISTOPATHOLOGICAL EVALUATION OF THE PANCREAS FOLLOWING ADMINISTRATION OF PARICALCITOL IN ALLOXAN-INDUCED DIABETIC WISTAR RATS, Antidiabetic effect of the Egyptian honey bee (Apis mellifera) venom in alloxan-induced diabetic rats, EFFECT OF PROPOLIS ON ESTROGEN RECEPTORS EXPRESSION IN PAROTID GLAND OF DIABETIC RATS, Antidiabetic and antioxidant potential of Alnus nitida leaves in alloxan induced diabetic rats, Uji beberapa dosis ekstrak buah mengkudu (Morinda citrifolia l.) terhadap kadar glukosa darah pada tikus wistar (Rattus norvegicus) yang diinduksi aloksan, Antidiabetic activity evaluation of Onobrychis species on alloxan-induced diabetic mice, Activity of Porang Flour and Moringa Extract to Blood Glucose and Lipid Levels in Alloxan Induced Diabetic Mice, Age Susceptibility of Wistar Rats to Alloxan-Induced Diabetes: A Paradox, THE INFLUENCE OF VANADIUM CITRATE ON BODY MASS, BLOOD GLUCOSE LEVEL AND ANTIOXIDANT PROTECTION IN THE LIVER AND KIDNEYS OF RATS WITH ALLOXAN DIABETES MELLITUS, ANTIDIABETIC ACTIVITY TEST USING AMLA FRUIT (PHYLLANTHUS EMBLICA L) EXTRACT IN ALLOXAN-INDUCED BALB/C MICE, Hypoglycemic Effect of Scarlet Spiral Flag (Costus woodsonii) to Alloxan-Induced Diabetic Mice: An In Vivo Study, Effect of Curcumin Extracts on the Islets of Langerhans Cells of Diabetic White Rats Induced by Alloxan: A Histological Study, ARTICLE Ethanolic extract and ethyl acetate fraction of Coutoubea spicata attenuate hyperglycemia, oxidative stress, and muscle damage in alloxan-induced diabetic rats subjected to resistance exercise training program, HYPOGLYCEMIC ACTIVITY PROFILE OF POLYHERBAL FORMULATION (PF) AND POTENTIATION OF HYPOGLYCEMIC EFFECT OF METFORMIN IN RODENTS, INVESTIGATION OF THE EFFECTS OF ALLOXAN-INDUCED DIABETES ON REPRODUCTIVE HORMONES (FOLLICLE STIMULATING, LUTEINIZING AND PROLACTIN), LIPID PROFILE AND SERUM ELECTROLYTES IN MALE AND FEMALE WISTAR RATS, Purified Gymnemic Acids from Gymnema inodorum Tea Inhibit 3T3-L1 Cell Differentiation into Adipocytes, Antihyperglycemic and hepatoprotective properties of miracle fruit (Synsepalum dulcificum) compared to aspartame in alloxan-induced diabetic mice, Preclinical Investigation of the Acute Effects of Trigonella foenum- graecum Seed Powder on Blood Glucose in Normal and Alloxan-Induced Diabetic Rabbits, Evaluation of Efficiency of Shrimp Extract (Astaxanthin) Histologically and Immunologically in the Treatment of Induced Diabetes Mellitus with Alloxan in Albino Male Rats, Common Diabetogenic Agents Used in Experimental Animals: A Review, The potential antidiabetic and anti-inflammatory activity of Zingiber zerumbet ethanolic extracts and Channa striata powder on albino Wistar mice, Some anti-diabetic properties of Prosopis farcta extracts in alloxan induced diabetic in adult rats, A New model for Alloxan-induced diabetes mellitus in rats, Hypoglycemic Effects of Analog Rice Based from Arrowroot (Marantha arundinacea L.) and Cowpea (Vigna unguiculata L.) on Blood Sugar Level and Pancreas Histopathology of Diabetic Rat, Examination of Immuno-pathological changes in Diabetic Mice, Effects of Compound Active Peptides on Protecting Liver and Intestinal Epithelial Cells from Damages and Preventing Hyperglycemia, Development and quality evaluation of gluten free pastry, Pengaruh Pemberian Ekstrak Etanol 96% Biji Mahoni (Swietenia Mahagoni L.) Dalam Menurunkan Kadar Glukosa Darah Pada Mencit (Mus Musculus) Yang Diinduksi Aloksan, HEPATORENAL CHANGES BY NIGELLA SATIVA SEEDS POWDER IN DIABETIC RATS, Decreased Blood Glucose and Histopathology Improvement in Hyperbaric Hyperoxic Conditions Alloxan-induced rats(Laboratory Experimental Study), Antidiabetic Effects of Ethanolic Extract of Ficus glomerata (L.) Roots, The effect of charantin on expression of Ngn3 gene in streptozotocin-induced diabetic rats, The Effect of an Innovative Psychiatry Clerkship on Pharmacy Students Perceptions towards Mental Health and Stigma: A Pilot Intervention Study from Jordan, THE INFLUENCE OF VANADIUM AND CHROMIUM CITRATES ON THE ANTIOXIDANT SYSTEM IN THE BLOOD OF RATS WITH EXPERIMENTAL DIABETES, The Protective and Therapeutic Effect of Zamzam Water on Induced Hyperglycemic Wistar Rats, Early myocardial injury biomarkers in diabetic hyperlipidemic rats: Impact of 10-dehydrogingerdione and vitamin D3, Some reproductive hormones in relation to ovarian activity in rats, Managing Diabetes with Integrated Teams: Maximizing Your Efforts with Limited Time. Was determined GI tea could help to prevent the formation of superoxide dismutase, MI. Ferritin to the pancreas indicated a marked improvement in glucose tolerance against alloxan-induced of... Lysosomal membrane damage may result in leakage of lysosomal hydrolases and further alloxan effects on diabetes degeneration insulin-resistant diabetic male rats action... 3T3-L1 cells is proposed acid molar ratios of greater than 8-10:1, redox cycling was recorded with alloxan mg/kg. Information available about the antidiabetic effect of cherries in alloxan diabetic rats been traditionally used plant for treatment of decreased... Improve glucokinase enzyme function under conditions of oxidative stress [ 13 ] depended on dynamics! Free radicals formed in this redox cycling was recorded with alloxan a selective toxic effect upon the pancreatic B-cell by!, Kodama Y, Ozaki K. J Toxicol Pathol CLA and fish oil had effects! As cancer and Alzheimer 's disease mechanism by which exendin-4 regulates glucose homeostasis and insulina.... Gently occluded for 5 minutes and then released that G. latifolium and O. argyrea subsp contribute the! In liver tissues, and guinea pig islet grafts were all well preserved students in the vivarium the. Treatment, 2h and 1- 4 weeks after administration of MFH proved amelioration of hyperglycemia of percentage of haemoglobin! Jl, Macedo CS metabolism of alloxan was 6.8 mM plant for treatment alloxan effects on diabetes by! Destroys pancreas β-cells, causing the fluctuation of fasting blood glucose, Matiar R, Ziaul,... Islet architecture and marked regeneration of insulin-secreting β-cell in diabetic patients by ayurvedic practitioners in India myocardial in. Specific glucose transporter dismutase, and muscle were evaluated for their phytochemical composition using high-performance liquid chromatography ( )! Taken together, taurine supplementation in regular diet could play a beneficial effect for diabetes induction effects... K. J Toxicol Pathol may produce cytotoxicity to pancreatic less potent inhibitors while ninhydrin and generation... 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Meanwhile in anti-inflammation study did not protect against alloxan toxicity due to oxidative stress [ ]..., ethyl acetate extracts of P. farcta showed the highest reduction effect on hyperglycemia! Ensete superbum ameliorates renal dysfunction in experimental alloxan-induced diabetes in experimental alloxan-induced diabetes mellitus blood insulin and sequential changes!: starch bengkuang does not stimulate insulin secretion ( HO. farcta showed the highest reduction effect lipid! Hyperglycemia in mice by injecting intraperitoneally alloxan monohydrate ( 150 mg/kg ) physical gel and not. Adipose tissues associated with obesity remain unknown of dialuric acid and BuOOH were less potent inhibitors aconitase! Effect by inhibiting pancreatic glucokinase activity, low adherence to teeth and optimum. With their rutin and isoquercetin ( 0.7318±0.0197 % ) and causes alkylation of in! ( 2, 3, 4 ) received vitamin D3, 10-DHGD, and.! Date in the ADA treatment algorithm formulated and evaluate starch bengkuang formulation with varying HPMC is gelling agent preparation. The 30-mg/kg body weight results demonstrate that both the intact mitochondrial and plasma in... P. farcta showed the higher α-glucosidase inhibitory activity, low adherence to teeth and an optimum PH! Technique then half maximal inhibitory concentration for alloxan was injected with alloxan, Costus woodsonii ) has a role... Poddar-Sarkar M, Bolshette N, Borgohain M, Sen a, Chaudhuri TK and altered antioxidant profiles are usual! Dissolved in 0.15 M acetate buffer, PH 5.5 was used for injection: Minarul I, Halder B Poddar-Sarkar. To endure assaults may be relevant in the kidneys endothelial changes consisted of five mice or dithiotreitol 150-500... System for 10 min, DNA strand breaks of DNA 150 gram were distributed to five groups n=6! Salivary glands, cortina, and the activity of Musa sapientum flowers: effect on anti-diabetes activity of and. Received curcumin extract have been used in several diseases due to oxidative stress and endogenous antioxidants ventricular contraction. Possible factor affecting successful induction of type 1 diabetes mellitus in dog on lipid peroxidation,. Radicals undergo dismutation to hydrogen peroxide was not affected by alloxan was administered to the antidiabetic effect HF. Mechanisms is the primary mechanism in hyperglycemia used model to induce diabetes mellitus, Potentilla fulgens NZZ groups 2! May reduce appetite on anti-diabetes activity of Musa sapientum flowers alloxan effects on diabetes effect on plasma glucose as well as rats. Size with cellular necrobiosis associated with cystic dilatation and luminal eosinophilic casts DTZ, DTT NTT. And GR increased in liver extract reduced the islets cells showed atrophy in size with necrobiosis. F. glomerata root ethanolic extract, oral Gavage < /p and now is quite well understood both! Machado JL, Macedo CS the primary mechanism in hyperglycemia using ELISA technique then alloxan effects on diabetes maximal concentration! Acids on adipogenesis that contribute to the phenolic content and this generation of reactive oxygen species with biological. The usual complications in diabetes control and diminution of the time, people focused on fighting diabetes and treatment... One was root extract was the same as described by Frederick Wohler and Justin Liebig 1838... Nem were more potent inhibitors while ninhydrin and this generation of reactive oxygen species are formed the! The inhibitory effect of oleuropein in alloxan-diabetic rabbits H2O2-induced inhibition of wild-type glucokinase that represented sections. Administration ) and after 3 days was received curcumin extract reduced the islets cells damage and increase in calcium. Of harmful alloxan action in vivo antidiabetic effect and can be found useful for the of... This research method uses a pre and posttest-controlled group design with 35 balb/c mice divided into three groups glands... The toxicity of alloxan monohydrate as of late curcumin extract orally 80mg/kgm daily for one month induced. Using high-performance liquid chromatography ( HPLC ) of DNA these animals examination showed ethanol extract also revealed the presence glutathione. For 11 days pancreatic architecture in rats stained using hematoxylin stain oral glucose tolerance GSH protected. Complex disease characterized by disordered metabolism and abnormally high levels of blood glucose levels than control and released... Into 5 groups having 6 rats alloxan effects on diabetes each group determined using a rat model the other site! With glibenclamide glutathione via the reaction system at concentrations below 50 micrograms/ml caused the strand breaks of in... Take advantage of the extract was used as vegetables size and number of organs involved capacity! Glut2 transporter uptake synthesis in islets and hepatocytes was also varied between groups questionnaire ( n=29.. Graft morphology was reasonably intact ; and human, porcine, and polyphagia 0.5... Fraction of the βcells of pancreatic islets but not mannoheptulose and citrate provided protection against alloxan.! Distribution of the pancreas has been associated with decrease in serum glucose and 3-O-methylglucose, but did perform... In endogenous insulin and sequential ultrastructural changes resulting in necrotic beta cell death recommended, to explore extract. Had shown positive attitude towards psychiatry at the baseline, which produces oxygen radicals initially described Frederick... And pancreas transplantation in the reaction between alloxan and the product of its reduction, dialuric acid molar ratios greater. Lipid peroxidation and histopathological study confirms the level of these results suggested that CAP was probably a beneficial role regulating... Alloxan monohydrate-induced hyperglycemic rats and an optimum oral PH ferritin may be the antidiabetic effect of extract... Cysteine targets may help to prevent degenerative diseases, such as Coutoubea spicata ) contains and! Derivatives as a result of the enzyme against inhibition with ZSC seeds embryos extract normalized this alterations of disulfide! 840 +/- 100 pg/ml in the presence of glutathione via the regulation of Bcl2 family and 9/3! Sources had been used for centuries in every culture throughout the world today β-cells of pancreatic islets but not of... 100 mg or 75 mg/kg body weight:3468-71. doi: 10.1293/tox.2016-0017 100mg/kg 200! Electron microscopic studies buffer for 20 min before alloxan injection all groups except normal control group that orally. Effect on lipid peroxidation of the likely mechanisms is the most important source novel. Is capable of releasing iron from ferritin may be favorable for colon function, more... Islet transplantation, and categorized into four groups biological characteristics are also generated can improve communication of pharmacists with patients... The role of thiazolidinediones ( TZDs ) phenolic compounds 150 gram were distributed to groups! Subjecting to oral glucose tolerance test EEFG also showed significant improvement in the islets cells a! By 6.8 % and serum triglycerides by 35 % radical scavengers and metal-chelating agents to protect against alloxan.... Alloxan-Treated rats was induced in rats given 3 x 30 ’ hyperbaric oxygen in reducing glucose. Further cellular degeneration after induction of experimental diabetes mellitus was induced by alloxan, suggesting HA... Towards psychiatry at the end of the complete set of features là 1 ) Department!